A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice.

Adenosine Receptor Signaling Contributes to Airway Inflammation and Mucus Production in Adenosine Deaminase-Deficient Mice

CaV2.3 channel and PKCλ: new players in insulin secretion

16 The Journal of Clinical Investigation http://www.jci.org Volume 115 Number 1 January 2005 1. Persson, C.G. 1985. On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter. Thorax. 40:881–886. 2. Barnes, P.J. 2003. Theophylline: new perspectives for an old drug. Am. J. Respir. Crit. Care Med. 167:813–818. 3. Fredholm, B.B., and Persson, C.G. 1982. Xanthine deri...

Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptor.

Adenosine is a signaling nucleoside that is generated in response to cellular injury and orchestrates the balance between tissue protection and the progression to pathological tissue remodeling. Adenosine deaminase (ADA)-deficient mice develop progressive airway inflammation and remodeling in association with adenosine elevations, suggesting that adenosine can promote features of chronic lung d...

Metabolic Consequences of Adenosine Deaminase Deficiency in Mice Are Associated with Defects in Alveogenesis, Pulmonary Inflammation, and Airway Obstruction

Adenosine deaminase (ADA) is a purine catabolic enzyme that manages levels of the biologically active purines adenosine and 2'-deoxyadenosine in tissues and cells. ADA-deficient mice die at 3 wk of age from severe respiratory distress. This phenotype is progressive and is linked to perturbations in pulmonary purine metabolism. The inflammatory changes found in the lungs of ADA-deficient mice in...

Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury.

Adenosine has been implicated in the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. In vitro studies suggest that activation of the A2B adenosine receptor (A2BAR) results in proinflammatory and profibrotic effects relevant to the progression of lung diseases; however, in vivo data supporting these observations are lacking. Adenosine deaminase-def...